ea0073oc3.6 | Oral Communications 3: Pituitary and Neuroendocrinology | ECE2021
Chen Xiao
, Simon Julia
, Luis Perez-Rivas
, Jörg Flitsch
, Honegger Jürgen
, Rachinger Walter
, Stalla Günter
, Reincke Martin
, Theodoropoulou Marily
IntroductionIntegrins are heterodimeric transmembrane proteins composed of alpha and beta subunits that mediate cell-cell and cell-extracellular matrix (ECM) interactions. Several integrins are overexpressed in human cancers and their ECM recognition motif, arginine-glycine-aspartate (RGD), is being utilized for tumour imaging and targeting.AimTo explore the expression and function of RGD-binding integrins in...